There are different ways to administer testosterone replacement therapy (TST), depending on your specific needs or the dosage form prescribed by your doctor. For example, injections or pellets are ideal for patients who prefer less frequent doses and seek long-lasting effects. Others, who prefer daily administration, may opt for gels, creams, or patches as alternatives. While effective, each form presents its own challenges.

Intramuscular (IM) injections are among the most popular methods of TRT treatment options and side effects. While effective for many people, side effects can occur. For example, formulations such as testosterone undecanoate (Aveed) can cause mild reactions, such as temporary pain or swelling at the injection site. In rare cases, more serious reactions, such as difficulty breathing or allergic reactions, can occur, although these are uncommon.

TRT creams and gels can cause side effects such as skin irritation, redness, or a rash at the injection site. Other potential problems include increased acne, oily skin, and the risk of hormonal transmission through skin-to-skin contact. Users may also experience mood swings, fluid retention, or changes in libido.

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